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Platelets maintain vascular barrier function in the absence of injury or inflammation

Journal of Thrombosis and Haemostasis, February 2021

Ho-Tin-Noé B, Le Chapelain O, Camerer E

There is now a consensus that a profound reduction in platelet numbers will not only impair classical hemostasis, but also the barrier function of the vascular wall. Recent evidence suggests that platelets not only seal vascular breaches caused by infiltrating neutrophils, but also coordinate the tightening of the circumferential endothelial belt around transmigrating leukocytes, thus preventing both bleeding and the extravasation of plasma during diapedesis.