Abstract
Background: Uncertainties remain about the impact of white matter hyperintensity (WMH) on prognosis after mechanical
thrombectomy.
Methods: In this retrospective study from a national prospective registry of patients with ischemic stroke due to large vessel
occlusion treated with mechanical thrombectomy, we assessed WMH volume using a quantitative semi-automatized segmentation
on baseline magnetic resonance imaging. We determined the association between WMH volume and the prognosis of
patients with ischemic stroke presenting between 2019 and 2022.

Conclusion: WMH volume is associated with increased risks of poor functional outcome and death at 90 days post mechanical
thrombectomy but not with the probability of recanalization success and posttreatment intracranial hemorrhage. The use of
semi-automatized tool to assess WMH volume may help better identify patients who would benefit the most from mechanical
thrombectomy and predict their prognosis.